PPARA and type 2 diabetes mellitus: The PPAR‐alpha variant was significantly associated with time to insulin therapy in the study population, but no replication study has been reported.75 In the ADDITION‐Denmark study, the association between a PRS (48 type 2 diabetes genetic risk variants) and time to first prescription (OHA or Insulin) from the diagnosis of type 2 diabetes was evaluated in patients with screen‐detected diabetes.