Eight insulin initiation‐based studies estimated the hazard of insulin initiation per 1% increase in baseline HbA1c (%) and aHR varied from 1.09 to 1.33.19, 24, 26, 41, 63, 65, 70, 78 All eight studies which assessed diabetes progression on the basis of treatment intensification reported baseline HbA1c was significantly associated with rapid treatment intensification.29, 37, 38, 51, 53, 60, 61, 62 A study conducted in France assessed the hazard of different categories of baseline HbA1c with HbA1c ≤ 7% as a reference in relation to treatment intensification. The gene discussed is INS; the disease is diabetes mellitus.