Analysis of the Look AHEAD trial data showed that younger age of diabetes diagnosis was associated with faster rate of insulin initiation, with an aHR 0.88 (95% CI 0.79‐0.98) per 10 year of age of diagnosis.55 In the prospective studies, two studies used time to insulin,43, 73 and one used diet failure as the progression phenotype,71 with all three studies concluding that younger age of diagnosis was associated with faster progression.43, 71, 73. The gene discussed is INS; the disease is diabetes mellitus.