INS and type 2 diabetes mellitus: In this crude study of diabetes “progression,” they showed a nominally significant association between this beta‐PRS and insulin treatment (β = 0.0131, SE = 0.006, P = .0431).74 Another study among Japanese population explored the association between a single nucleotide polymorphism (SNP) in Syntaxin IA and insulin requirement in individuals with type 2 diabetes.