INS and diabetes mellitus: Of the 22 retrospective studies, 10 examined the relationship between time to insulin and age of diabetes19, 23, 24, 26, 30, 63, 65, 70, 72, 78 while seven assessed time to treatment intensification,29, 37, 45, 51, 60, 61, 62 four assessed the initiation of antidiabetic drug27, 34, 49, 64 and one evaluated glycaemic deterioration.50 Most of the retrospective studies which considered initiation of insulin as a progression marker reported that a younger age at diagnosis is associated with a higher risk of diabetes progression.