The results illustrated that expression levels of GTSE1 (P < 0.05) and NMU (P < 0.05) were notably up-regulated, and expression levels of CDKN1C (P < 0.05) and FOS (P < 0.05) were notably down-regulated in lung adenocarcinoma (LUAD), as well as in lung squamous cell carcinoma, and significantly statistically significant. The gene discussed is CDKN1C; the disease is squamous cell lung carcinoma.