This type of response is typical of the so-called “inverted U-shaped” effect of DRD1, extensively studied in brain cortical cells, where both low (as in SCH) and high (as in COC) dopamine concentrations impact DRD1 signaling causing similar detrimental effects in cells function and cognition (Williams and Castner, 2006; González et al., 2016). The gene discussed is DRD1; the disease is spindle cell hemangioma.