Loss or down-regulation of the Ecadherin gene CDH1 at 16q22.1 is associated with breast cancer proliferation and invasion, MYC is an effective tumorigenic activator, a transcription factor, and a key regulator of cell growth, differentiation, and apoptosis (Amgalan and Lee, 2015; Nangalia et al., 2015). The gene discussed is MYC; the disease is breast carcinoma.