TUNEL assay indicated that the apoptosis rate of combination group, ZD55-IL-24 group, radiation group and PBS group in tumor tissues was (6.56 ± 2.70), (14.53 ± 3.58), (19.38 ± 4.41), (29.50 ± 3.36)%, respectively, with significant difference between the combination treatment group and the monotherapy group (Figure 5C, P < 0.01). This evidence concerns the gene IL24 and neoplasm.