In pancreatic cancer, SNHG15 was found to be up-regulated and to suppress the transcription of P15 and KLF2 (Kruppel Like Factor 2) by binding to EZH2 and the subsequent methylation at the promoter region of the histone 3 (H3K27me3) (165). The gene discussed is KLF2; the disease is familial pancreatic carcinoma.