Flow analysis for immune cells in the spleen of tumor bearing mice exhibited no change in CD11b+ myeloid, CD11b+/Ly6C+ monocyte and CD11b+/Ly6G+ neutrophil populations, but showed a significant increase in F4/80+ macrophages in the BMPR1a cKO tumor mice (Figure 4D). The gene discussed is ITGAM; the disease is neoplasm.