PLG and hereditary angioedema: When they dealt with PLG, one of the recently described HAE causal genes, they focused on the p.Lys330Glu mutation, a recurrent mutation described in more than 20 independent families from different European countries and Japan (Belbézier et al., 2018; Bork et al., 2018b; Germenis et al., 2018; Yakushiji et al., 2018; Recke et al., 2019), and also mentioned the p.Lys311Glu variant, described in three patients by Dewald (2018).