Unexpectedly, a mutant mouse carrying an adipose-specific deletion of Napepld, which encodes N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD), the NAE endocannabinoid synthesizing enzyme, is more susceptible to diet-induced obesity and metabolic dysregulation (Geurts et al., 2015). This evidence concerns the gene NAPEPLD and obesity due to melanocortin 4 receptor deficiency.