Functional annotations by Enrichr (Kuleshov et al., 2016) on KEGG (Kyoto Encyclopedia of Genes and Genomes) and GO (Gene ontology) suggest the target genes of TF MEF2C were enriched in the “NF-kappa B signaling pathway” (Pollheimer and Knöfler, 2005), “Primary immunodeficiency,” “Systemic lupus erythematosus,” “positive regulation of NF-kappaB transcription factor activity,” “positive regulation of immune response,” and so on (adjust p-value ≤ 0.05, Supplementary Figure S5). The gene discussed is MEF2C; the disease is systemic lupus erythematosus.