CARD11 and diffuse large B-cell lymphoma: Table 3 summarizes the heavy and light chain gene usage. Next generation sequencing together with flow cytometry-assisted cell sorting of bone marrow from 16 patients enabled Malecka and coworkers to identify recurrent mutations of KMT2D (69%) and CARD11 (31%) (36, 37). In diffuse large B-cell lymphoma, CARD11 mutations have been shown to induce constitutive activation of the NF-κB pathway (29, 38).