GZMB and wet macular degeneration: This is in contrast to the findings in human tissues presented here, where the majority of immunoreactivity was intracellular, However, sparse extracellular GzmB immunoreactivity was evident in wet AMD eyes, in a CNV lesion in a wet AMD eye, and in the choroids of a soft drusen eye and a GA eye (Figure 2C, Supplementary Figure 5).