The 1277 T>C polymorphism in the cfh DNA sequence, leading to a substitution of tyrosine to histidine at position 402 (Y402H), is the major risk factor for atrophic and neovascular (nAMD or wet AMD) forms of the disease, increasing the risk of AMD by 5–7% in homozygotes (2). This evidence concerns the gene CFH and age-related macular degeneration.