CD58, a ligand of the T lymphocyte CD2 protein, which functions in adhesion and activation of T lymphocytes (218–220) was found to be associated with SLC16A3 by similar entities analysis and this may be of significance in that engagement of this key receptor with CD2 is predominant in chronic antigen stimulation, which may be an important feature of sepsis, particularly with regard to natural killer cell (NK) cell dysfunction (221). This evidence concerns the gene CD58 and Sepsis.