The majority of these clusters were not connected in most disease and control states, except for adult sepsis and adult SIRS with the gene clusters for TDRD9, CD177, GPR84, PCOLCE2, FGF13 and SLC16A3 interconnected at various points, either directly or through overlapped gene connections (Supplementary Information S2, Table S6). Here, GPR84 is linked to systemic inflammatory response syndrome.