A gene interaction analysis based on these genes was conducted and 8 potent markers CD177, GPR84, FGF13, KLRK1, MYL9, PCOLCE2, TDRD9, and SLC16A3 were identified and selected for further investigation for their ability to stratify SIRS from sepsis and septic shock. The gene discussed is PCOLCE2; the disease is systemic inflammatory response syndrome.