In the present study, several proteins, including ECM1 (Mongiat et al., 2003), TGF-β2 (Allen et al., 1990), PDGFRA (Watanabe et al., 2002; Madarampalli et al., 2019), and SAA (Lee et al., 2006; Hatanaka et al., 2011), that regulate the proliferation of human arthritis were upregulated at both the mRNA and protein levels. This evidence concerns the gene ECM1 and arthritic joint disease.