NLRP3 and major depressive disorder: Based on the KEGG pathway analysis, downregulated DEGs were enriched for the Toll-like receptor signaling pathway, complement and coagulation cascades, NOD-like receptor signaling pathway, hepatitis B, measles, and influenza A. Recent data have demonstrated that NOD-like receptor pyrin containing 3 (NLRP3) activation appears to bridge the gap between immune activation and metabolic danger signals or stress exposure, which are key factors in the pathogenesis of MDD and other psychiatric disorders.