Inhibition of STAT3 by PD-L1 intrinsic signaling ensures the abrogation of interferon-mediated apoptosis (Gato-Canas et al., 2017), stimulates the inflammasome pathway in cancer cells (Theivanthiran et al., 2020), and directly inhibits PD-L1-positive T cells (Diskin et al., 2020). The gene discussed is CD274; the disease is cancer.