Controls hypertension and improves endothelial functionBy inhibition of ACE, enhancing Angiotensin 1-mediated phosphorylation of eNOSBy reducing the levels of vasoconstrictor peptide Endothelin-1Improves lipid profileBy upregulating lipid metabolism (ACOX1 and ACC)Ameliorates oxidative stress and inflammationBy enhancing phosphorylation of Nrf2 which upregulates HO-1, GST, NQO-1, SOD, CAT, GSH-Px and GSHBy decreasing the levels of MDA and ICAM, and regulation of mTOR/S6K signaling pathwaysReduces necrosisBy decreasing the levels of creatine phosphokinase. The gene discussed is RPS6KB1; the disease is hypertensive disorder.