The CANTOS clinical trial (2017) has provided evidence that in patients with elevated inflammation (hsCRP > 2 mg/L), a combination therapy of statins and canakinumab (IL-1β antibody) may be necessary to lower atherosclerosis risk (Ridker et al., 2017; Aday and Ridker, 2018; Reiner et al., 2019). The gene discussed is IL1B; the disease is atherosclerosis.