To explore the mechanism for such neuroprotection and promoting neurogenesis, IL-17 KO mice were used to observe the RNA-seq, immunohistochemistry staining, and western blots change, showing that knocking out IL-17 or administering after stroke contributes to regulating the Wnt signal pathway, repairing variety synapses, and activating neurogenesis and NSCs’ stemness in hippocampus. The gene discussed is IL17A; the disease is Stroke.