Remarkably, numerous human mutations were identified in the STAS domain of different SLC26 transporters causing many diseases including, diastrophic dysplasia (SLC26A2) (Cai et al., 2015), congenital chloride diarrhea (SLC26A3) (Dorwart et al., 2008), Pendred syndrome (SLC26A4) (Everett et al., 1997), and infertility (SLC26A8/A3) (Dirami et al., 2013; Rapp et al., 2017; Wedenoja et al., 2017). The gene discussed is SLC26A2; the disease is Diastrophic dwarfism.