MAPT and Alzheimer disease: Indeed, both the depletion of pericytes in the APPsw/0 mice (APPsw/0; Pdfgfb+ ⁣/−) (Sagare et al., 2013) and chronic cerebral hypoperfusion in the APPSwInd Tg mice (Kitaguchi et al., 2009; Yamada et al., 2011) aggravate AD pathology such as increasing Aβ deposition and tau phosphorylation followed by neuronal loss.