NOTCH3 and CADASIL: The importance of pericytes in SVD may be emphasized by the fact that one of the most common inherited cerebral SVD, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), shows aggregation of mutant Notch3 protein around capillary pericytes as well as arteriolar SMCs (Ihara and Yamamoto, 2016).