CD86 and early-onset autosomal dominant Alzheimer disease: High-dimensional single-cell mapping in EAE mouse CNS led to a unique activation profile comprising universal markers of microglia/macrophage activation including CD44, CD86, programmed death-ligand 1 (PDL1) as well as a decreased CD14 expression and increased major histocompatibility complex II (MHC II) and stem cell antigen-1 (Sca-1) expressions notably not detected in old mice or Alzheimer’s disease models (Mrdjen et al., 2018).