As shown in Figure 6, the exogenous recombinant Prx1 could block the inhibitory effects of PJ34 on post-stroke inflammation in the male MCAO mice,as the reduction of Iba-1, iNOS, and TNF-α mRNA levels induced by PARP-1 inhibition were reversed by Prx1. The gene discussed is PRDX1; the disease is stroke disorder.