Numerous studies have attempted to inhibit necroptosis by using nec-1 to reduce cell death and improve neurological function, thereby indirectly demonstrating the existence of necroptosis in the pathophysiological development after hemorrhagic stroke (Laird et al., 2008; King et al., 2014; Majmundar et al., 2016). Here, PCSK1 is linked to hemorrhagic stroke.