A total of 10 pathways were induced by ketamine: “Phosphatidylinositol signaling system,” “Retrograde endocannabinoid signaling,” “Nicotine addiction,” “Insulin secretion,” “Morphine addiction,” “Adherens junction,” “Glutamatergic synapse,” “Tight junction,” “Amphetamine addiction,” and “Aldosterone-regulated sodium reabsorption” (Figure 2D). The gene discussed is INS; the disease is nicotine dependence.