MAPT and early-onset autosomal dominant Alzheimer disease: Additionally, Curcumin have been reported for neuroprotective effect in other neurological disorder also such as Alzheimer’s, Parkinson’s, frontotemporal dementia, and Huntington disease etc. Administration of Curcumin improved the cell viability through various mechanism including inhibits amyloid formation and its toxicity in Alzheimer disease, reduce oxidative damage, inflammation, and synuclein protein aggregation in Parkinson disease, decrease aggregation of tau proteins in frontotemporal dementia.