CALB1 and Huntington disease: The studies on R6/2 transgenic murine model of HD have revealed a reduction in the expression levels of the calcium-binding proteins and cerebellar Purkinje cells (PCs) markers parvalbumin and calbindin that mostly occurred in the cerebellar PCs layer, PC loss was observed as well, and the decrease in the PC firing rate was detected in presymptomatic R6/2 mice (Dougherty et al., 2012).