Similar reduction in PC firing activity was previously observed in the studies with slices from murine models of ataxia in SCA2-58Q transgenic mice (Kasumu et al., 2012a, b), in SCA2-127Q mice (Hansen et al., 2013) and in the fast-activating/deactivating voltage-gated potassium channel Kv3.3 mutant SCA13 mice (Hurlock et al., 2008). This evidence concerns the gene ATXN2 and Ataxia.