Other multi-mutation models are the TgCRND8 and J20 mouse models expressing the AβPPSwe,Ind mutations, the APP/PS1 mice with the AβPPSwe/PS1M146L, AβPPSwe/PS1P264L, AβPPSwe/PS1L166Por the APPSwe/PS1ΔE9 mutation, the 5xFAD model with AβPPSwe,Lnd,Flo/PS1M146L,L286V mutation, and the 3xTg-AD triple transgenic mouse model with the AβPPSwe/TauP301L/PS1M146V mutations (Holcomb et al., 1998; Mucke et al., 2000; Chishti et al., 2001; Flood et al., 2002; Oddo et al., 2003; Oakley et al., 2006; Radde et al., 2006; Lindström, 2007; Hall and Roberson, 2012; Graybeal et al., 2015). This evidence concerns the gene PSEN1 and Alzheimer disease.