To study the function of CXCL14 in the development of sepsis-associated AKI, the transgenic (Tg) mice that overexpress CXCL14 (CXCL14-Tg mice) and a mouse model of sepsis by cecal ligation and puncture (CLP) were used in this study. This evidence concerns the gene CXCL14 and acute kidney injury.