Furthermore, epigenetic regulators histone deacetylases (HDACs) and demethylases (DMT) and DNA repair enzyme poly-(ADP-ribose) polymerase 1 (PARP1) are transcriptional partners of EWS-FLI1, which formed a solid ground for use of PARP inhibitor olaparib, HDAC inhibitor entinostat, and DMT inhibitor HCI-2509 in preclinical and clinical studies for Ewing's sarcoma therapy [27, 30, 31]. Here, DMTN is linked to Ewing sarcoma.