Based on cut-off values, participants were divided as obese (BMI > 30), hypertensive (SBP/DBP > 130/85), low HDL (HDL-cholesterol <40 mg/dL for men and <50 mg/dL for women), hypertriglyceridemia (>1.7 mmol/l), hypercholesterolemia (>5.7 mmol/l), high glucose (>5.6 mmol/l) and MetS (IDF criteria) and analyzed the effect of ANGPTL8 gene variants on the above classified variables. This evidence concerns the gene ANGPTL8 and familial hypercholesterolemia.