Taking into account the involvement of ANGPTL8 gene and its variants in lipid and glucose metabolism; the fact that alterations in lipid and glucose metabolism predisposes to metabolic disorders; and the scarcity of data on the associations of these gene variants on MetS and its components especially in Saudi population, we investigated the role of ANGPTL8 gene variants in MetS phenotypes among adult Saudis. The gene discussed is ANGPTL8; the disease is metabolic syndrome.