Nevertheless, while some suggest no role of betatrophin in beta-cell proliferation9, yet there are evidences in the literature which suggest that the factors related to metabolic diseases such as age, gender, waist circumference, total/HDL cholesterol ratio and renal function maybe associated with the circulating levels of betatrophin10 suggesting that it may play a role in the emergence and progression of metabolic diseases. The gene discussed is ANGPTL8; the disease is metabolic disease.