Thermosponge nanoparticles (TSNs) composed of mPEG-PLGA loaded with paclitaxel (PTX) in the core and IL-2 in the shell (PTX/IL-2-TSNs) reduced tumor growth and metastasis in a murine melanoma model to a greater extent than did either TSNs loaded with PTX or IL-2, demonstrating the benefit of combining chemotherapy with an immune adjuvant [51]. The gene discussed is IL2; the disease is melanoma.