AIF1 and viral infectious disease: In the sensory epithelium of Irf5−/− mice where M1 macrophage polarization is suppressed25,38, induction of the genes encoding F4/80, Mac-1 and Iba1 macrophage markers, suppression of Cd200r1 (Fig. 6b), and migration of the SCs in response to virus infection (Fig. 6a,c, compared to Fig. 2a) were all impaired.