Integrins may trigger a variety of signaling pathways and regulate cell survival, differentiation, and migration, including cytoplasmic alkalization, calcium influx, potassium channel activation, activation of MAP kinase cascades and tyrosine phosphorylation of regulatory proteins.27,28 The results of coimmunoprecipitation in our study verified that integrin α2 indeed interacts with integrin β1 in NSCLC cells (Fig. 5f). The gene discussed is KCNA3; the disease is non-small cell lung carcinoma.