In addition, conditioned medium from the culture of BCL-w-overexpressing cells promoted tumorigenicity of GBM, which was associated with elevated levels of SRY-box 2 (SOX-2), NANOG, octamer-binding transcription factor 4 (OCT4), Nestin, NOTCH2, Musashi and CD133103. The gene discussed is SOX2; the disease is glioblastoma.