miR-122-dependent downregulation of BCL-w rendered HCC cells sensitive to adriamycin and vincristine131, while inhibition of BCL-w and BCL-2 as a result of cyclooxygenase-2 (COX-2) silencing potentiated TRAIL-mediated apoptosis in HCC cells132. Here, BCL2L2 is linked to hepatocellular carcinoma.