To investigate the role of RBMX in the regulation of HIV-1 infection, cells with knockdown of RBMX were generated by transducing Jurkat T cells with lentiviruses containing RBMX-specific short hairpin RNAs (shRNAs) (Fig. 1A) and infected with pseudotyped HIV-luc/VSV-G (HIV luciferase/vesicular stomatitis virus G) for 2 days. The gene discussed is RBMX; the disease is HIV-1 infection.