Currently a number of phase 2 studies are assessing the potential of PD-L1-directed PET imaging e.g. 89Zr-durvalumab or 89Zr-pembrolizumab to determine SUV of radiolabeled IO uptake in tumor lesions, correlate between tumor uptake and PD-L1 expression as determined by immunohistochemistry and potentially predict response rate (NCT03829007), (NCT03853187), (NCT02760225). This evidence concerns the gene CD274 and neoplasm.