RELN and epilepsy: Further, human studies as well as genetic and chemical-induced mouse models of epilepsy showed association between reduced Reelin mRNA expression and GCD [13, 16, 22, 24, 27, 42]; although there is discrepancy in the type of Reelin+ cells (early-born Cajal-Retzius cells or late-born hilar interneurons) considered to be associated with GCD.