On the other hand, IL-21 stimulated mammalian target of rapamycin (mTOR) complexes 1 and 2, abrogated the autophagy, differentiation, and function of Treg cells in a STAT3-dependent manner, and drove expansion of Th17-like cells in SLE patients [60, 61]. Here, MTOR is linked to systemic lupus erythematosus.