Most of the increased CD4+Foxp3+ T cells in the peripheral blood of active SLE patients originated from tTreg cells, as determined by the completely demethylated status at the TSDR of the foxp3 gene, and were consistent with naïve or resting Treg cells, as reported by Miyara et al. [36]. This evidence concerns the gene FOXP3 and systemic lupus erythematosus.