The ATR lies upstream of CHK1 and phosphorylates numerous factors including Werner syndrome ATP-dependent helicase (WRN), SWI/SNF-related matrix-associated actin-dependent regulator of chromatin sub-family A-like protein 1 (SMARCAL1), and Fanconi anaemia complementation group I (FANCI), which may help preserve replication fork stability and control cell-cycle progression [76–78]. This evidence concerns the gene WRN and anemia.