AKT1 and clear cell adenocarcinoma: The high frequency of ARID1A and PIK3CA mutations in OCCC theoretically results in a higher activity of the PI3K–AKT–mTOR pathway, which is believed to be a critical pathway on basis of the genomic characterization of OCCC; on the other hand, phosphoinositide 3-kinase (PI3K)-related pathways are known to be essential in the carcinogenesis of clear cell carcinoma, endometrioid carcinoma, and mucinous carcinoma [28].