PTEN and ovarian cancer: In previous studies, molecular biology and genetic research using recent microarray experiments has shown that OCCC is distinct from other EOCs and has a unique genetic profile, characterized by frequent ARID1A (50%) and PIK3CA (40%) mutations, MET amplification, and rare p53, BRCA1, and BRCA2 mutations; however, p53 and PTEN mutations are also frequently observed in ovarian cancers in general [27].