The C3a peptide, modulating inflammation and possessing antimicrobial activity, could contribute to tumor proliferation, invasion and metastasis, and is also shown to be crucial for leukocyte infiltration of the tumors [37], and generalized up-regulation effects and the activation of an alternative pathway of the complement system during the progression of OCCC in our analytic results were mentioned in Table S4. Here, C3 is linked to neoplasm.