PROM1 and cancer: Among the identified genes, lower levels of stem cell markers such as CD133 (prominin1), DCLK1, LIN7, SOX4, SERPIN3, or TP63; motility-related pathways such as PRRX1, MMP7, or Claudin; cell signaling as FOS or JUN; or cancer-related genes such as K-RAS were detected in shERBB4 cells (Table S1).