Although non-celiac gluten sensitivity (NCGS, correctly NCWS) had been described as a distinct clinical condition about 40 years ago [12], it is now identified as a syndrome, characterized by symptoms which can involve the gastrointestinal tract, the nervous system, the skin, the female reproductive tract, and other organs, following the ingestion of gluten/wheat, in subjects who do not suffer from CeD or IgE-mediated wheat allergy [13,14,15]. The gene discussed is IGHE; the disease is wheat allergic reaction.