Ms_YrbE3A infection resulted in the highest concentrations of pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6, MCP-1, IL-1α, IL-12p70, and IFN-γ, in the lungs at 2 d PI and later decreasing rapidly from 4 to 21 d PI. This evidence concerns the gene CCL2 and infection.