Our results revealed that the phosphorylation of MAPK-p38 (p-p38) and NF-κB p65 (p-p65) was significantly enhanced by Ms_YrbE3A infection at early stages, but phosphorylation of MAPK-JNK (p-JNK) occurred at late stages, showing a time-independent manner. This evidence concerns the gene MAPK8 and infection.