A specific and pervasively important oncogenic role of METTL3 was described by Li and co-authors [50], who showed that METTL3 modulates the nonsense-mediated RNA decay (NMD) of splicing factors mRNAs, and, as a consequence, can induce extensive alternative splicing isoform switches able to deeply perturb the metabolism of glioblastoma cells. Here, METTL3 is linked to glioblastoma.