This might explain, at least in part, the contrasting results obtained by different groups in this field, as for example the correlation of m6A RNA methylation extent with differentiation of glioblastoma stem cells, or the effects of METTL3 knock-down on the in vitro self-renewal and in vivotumorigenicity of these cells (compare [39] with [48]). This evidence concerns the gene METTL3 and glioblastoma.