This work is clearly focused on oligodendrocyte determination in physiological and pathological hypomyelination conditions, but it is worth underlining that Olig2, besides its role as master factor in oligodendrocyte development, has also an important function in GBM cell reprogramming, genotoxic resistance, and tumor phenotype plasticity [62,63,64]. This evidence concerns the gene OLIG2 and glioblastoma.