Starting from the evidence of the epigenetic silencing of the promoter of the NSUN5 gene through the hypermethylation of a CpG island in several glioma cell lines, correlating with NSUN5 transcriptional silencing, this group showed that NSUN5 behaves as a tumour suppressor in several in vivo mouse models of glioma growth. Here, NSUN5 is linked to central nervous system cancer.