The analysis of the data present in the TCGA database led to discover that: (i) 28% of the annotated gliomas shows CpG island hypermethylation in NSUN5 promoter, correlating with transcript downregulation, (ii) this condition is particularly enriched in low-grade gliomas compared to GBM, (iii) NSUN5 hypermethylation and low levels of expression positively correlate with longer overall survival in all glioma grades. This evidence concerns the gene NSUN5 and central nervous system cancer.