Genetic studies in CCM patient cohorts have led to the identification of three disease genes, CCM1/KRIT1, CCM2, and CCM3, which have been implicated in all major mechanisms of vascular integrity maintenance and endothelial barrier function, including the coordination of redox signaling and autophagy governing cell homeostasis and stress responses [43,171,172,173,174,175,176,177,178,179,180]. This evidence concerns the gene KRIT1 and cerebral cavernous malformation.