When the whole population was studied (participants with or without obesity), weight, BMI, FM, LBM and leptin were positively correlated with aBMD at all bone sites, while osteocalcin (OC), log sCTx, Trap-5, adiponectin and log irisin were negatively correlated. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.