The importance of the PVP motif in epilepsy is further strengthened by high resolution genomic screening, which has also identified a KCNA1 copy number variant (CNV) affecting this region in a three year old child with severe myoclonic epilepsy of infancy (SMEI) who succumbed to sudden unexpected death in epilepsy (SUDEP) [88]. The gene discussed is KCNA1; the disease is epilepsy.