In contrast with EA1-associated mutations, which span the whole length of Kv1.1, KCNA1 mutations associated with epilepsy or a family record of seizures appear to preferentially localize in certain domains of the Kv1.1 protein, specifically in the S1/S2 helices and the pore domain (Table 1; Figure 1 and Figure 2). This evidence concerns the gene KCNA1 and epilepsy.