Similarly, the metastasis-promoting miRNA miR-9 was found to promote metastatic ability in breast cancer by targeting multiple metastasis suppressors including E-cadherin, involved in EMT, and leukemia inhibitory factor receptor (LIFR), that suppress metastasis formation by inactivating the Hippo signaling pathway and was recently reported to be a breast cancer suppressor of bone metastasis [67,68,69]. This evidence concerns the gene LIFR and breast cancer.