The main findings of our study are: (1) a set of miRNAs are selectively expressed in normal colonic ALDH-positive SCs, (2) specific miRNAs in this set are aberrantly expressed in CRC CSCs, (3) one of these aberrantly expressed miRNAs, miRNA92a, targets the 3′UTR of the LRIG1 SC gene, and (4) miRNA92a regulates proliferation of human CRC cells. Here, LRIG1 is linked to colorectal carcinoma.